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在临床治疗中,中西药物联合应用较为普遍。然而,对中西药物联用的副作用有的医师却没有重视,本文对此作一些阐述。 1 产生络合物,降低功效 四环素与含有金属离子的中药,如云母石、石决明等合用,由于中药中的铁、钙、钾等金属离子易与四环素类药物中的酰胺基、酚羟基结合,形成肠道难于吸收的金属络合物,影响四环素的生物利用度。酶制剂与含有大量鞣酸的中药合用,鞣酸易与酶制剂中酰胺键或肽键形成牢固络合物,使酶失活。例如胃蛋白酶与大黄及其制剂合用,大黄通过吸收或络合抑制胃蛋白酶的消化作用。 2 产生毒性,导致药源性疾病 西药溴化物、碘化物如三溴片、碘化钾等与朱砂丸、救急散等含汞中药合用,易生成氯化汞等刺激性
In clinical treatment, the combination of Chinese and Western medicine is more common. However, some doctors have not paid much attention to the side effects of Chinese and Western medicine. This article gives some explanations. 1 produce complex, reduce efficacy Tetracycline and containing metal ions of traditional Chinese medicine, such as mica, stone Cassia and so on, due to Chinese medicine in the iron, calcium, potassium and other metal ions and tetracycline drugs easily amide, phenolic hydroxyl Combined to form intestinal difficult to absorb metal complexes, affecting the bioavailability of tetracycline. Enzyme preparation and containing a large number of tannin Chinese medicine, tannin and enzyme easily with the amide bond or peptide bond to form a strong complex, the enzyme inactivation. For example, pepsin and rhubarb and their preparations, rhubarb by absorption or complex inhibition of pepsin digestion. 2 toxicity, leading to drug-induced diseases Western medicine bromide, iodide such as tribromide tablets, potassium iodide and cinnabar pills, emergency powder and other mercury-containing traditional Chinese medicine combined, easy to generate mercury chloride and other irritant