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本文应用放免法检测了50例急性发作期男性肺心病患者及26名正常健康男性之血浆睾酮(T)、雌二醇(E_2)、血清黄体生成激素(LH)、卵泡刺激素(FSH)水平及对黄体生成激素释放激素(LRH)刺激的反应性。结果表明,急性发作期血浆T值明显降低(P<0.01),E_2/T比值显著升高(P<0.01);缓解期二者均恢复至对照水平。急性发作期患者对LRH刺激之反应亦有所减退。血浆E_2、血清LH和FSH水平均无明显变化。患者血浆T值与PaO_2呈明显正相关,E_2/T比值与PaO_2,呈明显负相关,T值、E_2/T比值与PaCO_2均无相关关系。作者提出:缺氧是导致男性肺心病患者急性发作期下丘脑-垂体-性腺轴功能改变的重要影响因素。
In this study, the levels of plasma testosterone (T), estradiol (E_2), serum luteinizing hormone (LH), follicle stimulating hormone (FSH) in 50 patients with acute pulmonary heart disease and 26 normal controls were measured by radioimmunoassay And reactivity to luteinizing hormone releasing hormone (LRH) stimulation. The results showed that plasma T value was significantly decreased (P <0.01) and E 2 / T ratio was significantly increased (P <0.01) in acute stage of attack; both of them recovered to the control level in remission stage. Patients with acute exacerbations also responded to LRH stimulation. Plasma E2, serum LH and FSH levels did not change significantly. There was a positive correlation between plasma T value and PaO 2, and a negative correlation between E 2 / T ratio and PaO 2. There was no correlation between T value and E 2 / T ratio and PaCO 2. The authors suggest that hypoxia is an important factor in the functional changes of hypothalamus-pituitary-gonad axis in acute episodes of pulmonary heart disease in men.