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由于细胞线粒体膜的充电时间常数远小于细胞核膜与细胞膜的充电时间常数,在ps电场脉冲作用下,线粒体膜将先于细胞核膜与细胞膜受到脉冲的影响。为此,整合无创治疗的应用需求以及电场脉冲靶向诱导肿瘤细胞凋亡的窗口效应,提出通过冲激脉冲辐射天线将ps脉冲聚焦于肿瘤组织,使肿瘤细胞线粒体跨膜电位发生变化而崩溃,启动线粒体途径的凋亡靶向诱导,实现肿瘤的无创治疗,初步实验与仿真结果表明该理论的可行性。根据超宽带天线设计理论,设计了一种用于辐射ps电场脉冲的冲激脉冲辐射聚焦天线,初步优化结果显示当金属板与x轴夹角β为90°~95°以及单圆锥辐射器的半张角α为30°~35°时,可以使天线在靶点位置得到最大的场强分布。
Because the charging time constant of the mitochondrial membrane is far less than the charge time constant of the nuclear membrane and the cell membrane, the mitochondrial membrane will be pulsed before the nuclear membrane and the cell membrane under the effect of ps electric field pulse. Therefore, integrating the application requirements of noninvasive treatment and the window effect of electric field pulse-induced tumor cell apoptosis, we proposed to focus the ps pulse on the tumor tissue by the pulsed pulsed radiation antenna and make the mitochondrial transmembrane potential of tumor cells change and collapse, Start the mitochondrial pathway of apoptosis-targeted induction, to achieve noninvasive treatment of the tumor, preliminary experiments and simulation results show the feasibility of the theory. According to the UWB antenna design theory, an impulse pulsed focusing antenna is designed for the radiation of ps electric field pulses. The preliminary optimization results show that when the included angle β between the metal plate and the x axis is 90 ° ~ 95 ° and the single-cone radiator When the half-angle α is 30 ° ~ 35 °, the antenna can obtain the maximum field intensity distribution at the target position.