【摘 要】
：
A comparison of 99mTc-CQDO and 99mTc-CQDO-MeB has been made for biodistribution and pharmacokinetics. 99mTc-CQDO and its adducts of methaneboronicacid 99mTc-CQD
【机 构】
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National Key Laboratory of Nuclear Medicine
论文部分内容阅读
A comparison of 99mTc-CQDO and 99mTc-CQDO-MeB has been made for biodistribution and pharmacokinetics. 99mTc-CQDO and its adducts of methaneboronicacid 99mTc-CQDO-MeB were prepared by the reduction of Na99mTcO4 withSnCl2.2H2O inaqueous solution. Radiochemical purity of 99mTc-CQDO and 99mTc-CQDO-MeB determinedby TLC were over 95% after extraction.Biodistributions of 99mTc-CQDO and99mTc-CQDO-MeB in micedemonstrated that both of them could be easily absorbed bymyocardium,and the peak uptake of each were 10.83±2.2%ID/g and11.84±1.69%ID/g,respectively. 99mTc-CQDO showed rapid clearance from myocardialtissuewhile 99mTc-CQDO-MeB had long retention in heart muscle. The myocardialuptakeof 99mTc-CQDO was only 5.88±1.66%ID/g at 10 min, and theuptake of 99mTc-CQDO-MeBwas 7.42±0.17%ID/g at 60 min. Theelimination of each from blood has a biexponentialpattern, the firstT1/2 is1.38 and 1.5 min, respectively. The partition coefficientof 99mTc-CQDO and 99mTc-CQDO-MeB were 20 and 25 at pH 7.40, respectively.
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