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报道了 6个具有类似结构的多羟基甾醇的合成和它们的抗肿瘤细胞活性 .发现此类化合物的细胞毒性与其分子中双键存在与否有着密切关系 .当甾核或支链中双键被饱和时 ,其细胞毒性均明显降低 .甾醇(5 )和 (8)对胃癌 (MGC)、宫颈癌 (HEL A)细胞的生长具有一定的抑制作用 .
Reported the synthesis of six polyhydroxysterols with similar structure and their anti-tumor activity, and found that the cytotoxicity of these compounds is closely related to the presence or absence of double bonds in their molecules.When a double bond in a steroidal or branched (5) and (8) inhibited the growth of gastric cancer (MGC) and cervical cancer cells (HEL A) in a dose-dependent manner.