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目的:探讨S100A11在胃癌和正常胃粘膜组织中的表达及意义。方法:采用RT-PCR和Western Blot技术检测21对配对胃癌组织和正常胃粘膜组织中S100A11的表达情况。结果:胃癌组织S100A11 mRNA的表达量(1.26±0.03)高于正常胃癌粘膜组织中的表达量(0.75±0.04),两组比较差异有统计学意义(p<0.05)。S100A11蛋白在胃癌组织中的表达量(0.94±0.05)明显高于在正常胃粘膜组织中的表达量(0.39±0.05),两组比较差异有统计学意义(p<0.05)。结论:S100A11在胃癌组织中的表达量明显高于正常组织,提示其与胃癌的发生和发展有关。
Objective: To investigate the expression and significance of S100A11 in gastric cancer and normal gastric mucosa. Methods: The expression of S100A11 in 21 paired gastric cancer tissues and normal gastric mucosa tissues was detected by RT-PCR and Western Blot. Results: The expression of S100A11 mRNA in gastric cancer tissue was significantly higher than that in normal gastric mucosa (1.26 ± 0.03) (0.75 ± 0.04) (p <0.05). The expression of S100A11 protein in gastric carcinoma was significantly higher than that in normal gastric mucosa (0.94 ± 0.05) (0.39 ± 0.05) (p <0.05). Conclusion: The expression level of S100A11 in gastric cancer tissues is significantly higher than that in normal tissues, suggesting that S100A11 is associated with the occurrence and development of gastric cancer.