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为通过脐血了解窒息新生儿体内凝溶功能的改变情况 ,对38例窒息新生儿及20例正常新生儿作前瞻性研究 ,分别在出生时取脐血、病程极期及恢复期取静脉血 ,应用ELISA法及反向血凝法分别检测血浆D -二聚体和纤维蛋白降解产物(FDP)。结果发现窒息新生儿脐血及极期外周血D -二聚体明显高于恢复期和正常新生儿 (P<0.05) ,重度窒息患儿升高更明显 (P<0.01) ,而脐血D -二聚体与极期静脉血D -二聚体差异无显著性 (P>0.05) ;重度窒息患儿脐血及极期外周血FDP值与正常儿相比差异有极显著性。提示通过脐血D -二聚体测定 ,可了解窒息新生儿体内凝溶功能变化 ,从而为早期诊治提供可靠依据
In order to understand changes of coagulation function in neonatal asphyxia neonates through umbilical cord blood, 38 cases of asphyxia neonates and 20 normal neonates were prospectively studied. Cord blood was taken at birth, The plasma D - dimer and fibrin degradation products (FDP) were detected by ELISA and reverse hemagglutination respectively. The results showed that neonatal asphyxia neonatal cord blood and peripheral blood D - dimer was significantly higher than the recovery and normal neonates (P <0.05), severe asphyxia children increased more significantly (P <0.01), while umbilical cord blood D - There was no significant difference between dimer and venous blood D - dimer (P> 0.05). There was significant difference between FDP value of cord blood and peripheral blood in children with severe asphyxia. It is suggested that the change of coagulation function in neonatal asphyxia can be understood through the determination of D-dimer in umbilical cord blood, so as to provide a reliable basis for early diagnosis and treatment