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目的： 研究胃腺癌组织中ＣＤ４４ 的表达及其与淋巴结转移和预后的关系。方法： 应用免疫组化方法， 对１０５ 例胃腺癌组织中ＣＤ４４ 的表达进行了观察， 并对其中６２ 例患者做了随访。结果： ＣＤ４４ 和ＣＤ４４ｖ６ 基因的表达率分别为５４－３ ％ 和４８－６ ％ 。ＣＤ４４ｖ６ 在胃腺癌组织中的表达与癌细胞的分化、浸润深度， 以及临床分期和预后有关（Ｐ＜ ０－０５）， 而ＣＤ４４ 的表达则与上述临床病理指标无关。另外， 抗ＣＤ４４ 和抗ＣＤ４４ｖ６ 抗体的阳性反应， 与癌细胞的淋巴结转移有关（ＣＤ４４ｖ６， Ｐ＜ ０－０１ ； ＣＤ４４ ， Ｐ＜ ０－０５） 。结论： ＣＤ４４ 的表达可用于胃癌患者的病情监测， 其中ＣＤ４４ｖ６ 有望作为判断预后的一个指标。
Objective: To study the expression of CD44 in gastric adenocarcinoma and its relationship with lymph node metastasis and prognosis. Methods: Immunohistochemical method was used to observe the expression of CD44 in 105 cases of gastric adenocarcinoma and 62 cases were followed up. Results: The expression rates of CD44 and CD44v6 genes were 54-3% and 48-6 %, respectively. The expression of CD44v6 in gastric adenocarcinoma tissues was related to the differentiation and infiltration depth of cancer cells, as well as clinical stage and prognosis (P < 0-05). The expression of CD44 was not related to the above clinicopathological parameters. In addition, positive responses to anti-CD44 and anti-CD44v6 antibodies were associated with lymph node metastasis in cancer cells (CD44v6, P<0-01; CD44, P<0-05). Conclusion: The expression of CD44 can be used to monitor the condition of patients with gastric cancer, of which CD44v6 is expected as an indicator of prognosis.