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目的探讨血管紧张素Ⅲ型(AT)受体拮抗剂(ARB1)坎地沙坦对老年人高血压患者脉压的影响。方法符合2004年中国高血压防治指南(实用本)高血压病诊断标准的高血压病1、2级患者96例,治疗组60例,口服坎地沙坦4～8mg,1次/d,对照组36例,口服依那普利5～10mg,1次/d。结果用药5个月后坎地沙坦组,依那普利组收缩压(SBP),舒张压(DBP)均显著下降(P分别<0.001,<0.01),坎地沙坦组脉压(PP)亦有明显缩小(P<0.01)。结论坎地沙坦不仅是安金可靠的降压药,而且可以缩小脉压,具有器官保护作用。可作为老年高血压一线用药。
Objective To investigate the effect of candesartan, an angiotensin Ⅱ type receptor (AT) receptor antagonist (ARB1), on pulse pressure in elderly hypertensive patients. Methods According to the guidelines for the prevention and treatment of hypertension in 2004 in China (Practical), 96 patients with grade 1 and 2 hypertension and 60 patients in treatment group were given candesartan 4 ~ 8mg once a day, Group 36 cases, oral enalapril 5 ~ 10mg, 1 time / d. Results The systolic blood pressure (SBP) and diastolic blood pressure (DBP) of candesartan group and enalapril group were significantly decreased (P <0.001, <0.01 respectively) ) Also significantly reduced (P <0.01). Conclusion Candesartan is not only a reliable antihypertensive drugs, and can reduce pulse pressure, with organ protection. Can be used as senile hypertension first-line medication.