论文部分内容阅读
目的:研究可溶性药物美司钠缓释微球的最佳制备工艺及体外释药,比较O/W溶剂挥发法与W/O/W复乳溶剂挥发法的优缺点。方法:采用乳化-溶剂挥发法制备美司钠聚乳酸微球。由紫外分析法测定微球的药物含量及体外释药量,正交实验确定2种方法的最佳配比。结果:聚乳酸微球具有很好的控释能力。采用W/O/W复乳溶剂挥发法比O/W溶剂挥发法制备的缓释微球在包埋率、载药量和药物释放性能上更好,而O/W法要更简单、经济。找出可溶性药物微球制备工艺最佳配比。
OBJECTIVE: To study the optimal preparation process and in vitro release of the soluble drug, mesna sustained-release microspheres, and to compare the advantages and disadvantages of the volatile O / W solvent method and the W / O / W double-emulsion solvent evaporation method. Methods: Mesima s polylactic acid microspheres were prepared by emulsification-solvent evaporation method. The drug content and drug release of the microspheres were determined by UV analysis. The optimal ratio of the two methods was determined by orthogonal experiment. Results: Polylactic acid microspheres have good ability of controlled release. The sustained-release microspheres prepared by the W / O / W double-emulsion solvent volatilization method is better than the O / W solvent evaporation method in the embedding rate, drug loading capacity and drug release performance, while the O / W method is simpler and more economical. Find out the best proportion of preparation process of soluble drug microspheres.