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目前制造片剂用的扑热息痛原料,为白色或淡粉红色颗粒状结晶。颗粒间结聚力较强,结晶不易粉碎。按照一般制湿颗粒方法压片,常有严重的掀盖现象。颗粒中含水分,能改善颗粒的弹性,增加颗粒的可塑性并增加颗粒间的内聚力。因此,用一般制湿颗粒方法压片时,水分需保持在2.5%以上,过低则掀盖。然而,过量的水分可使片剂贮存期间质量不稳定。
Paracetamol tablets currently used for the manufacture of raw materials, white or light pink granular crystals. Strong cohesion between particles, crystallization is not easy to smash. In accordance with the general method of wet granulation tablets, often a serious flip phenomenon. The moisture content of the particles can improve the elasticity of the particles, increase the plasticity of the particles and increase the cohesion between the particles. Therefore, the general method of wet granulation tablets, the water needs to be maintained at 2.5% or more, the flip cover is too low. However, excess moisture can destabilize the tablet during storage.