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目的探讨HbA_1c水平与冠状动脉病变程度的相关性及临床意义。方法对临床疑诊或诊断为冠心病(CHD)而行冠状动脉造影的541例患者进行HbA_1c测定分组,评价HbA_1c水平与CHD、冠脉狭窄程度(Gensini积分法)、冠脉狭窄支数及接受PCI治疗等的相关性。结果随HbA_1c水平升高,CHD患病率显著上升(P<0.01),Spearman等级相关分析显示,HbA_1c与CHD、病变支数、Gensini积分和接受PCI治疗显著相关(r=0.211,P<0.01;r=0.213,P<0.01;r=0.233,P<0.01;r=0.137,P<0.01)。Logistic多元逐步回归分析结果显示,HbA_1c为CHD的独立危险因素(OR=1.436,95%CI为1.128～1.828,P<0.01)。结论 HbA_1c与冠脉病变程度呈正相关,长期升高可能促进CHD的发生。
Objective To investigate the correlation between the level of HbA_1c and the severity of coronary artery disease and its clinical significance. Methods HbA 1c was determined in 541 patients with clinically suspected or diagnosed coronary heart disease (CHD) undergoing coronary angiography. The levels of HbA 1c, CHD, degree of coronary artery stenosis (Gensini score), number of coronary stenosis PCI and other related. Results The prevalence of CHD was significantly increased with the increase of HbA_1c level (P <0.01). Spearman rank correlation analysis showed that HbA_1c was significantly associated with CHD, lesion count, Gensini score and PCI (r = 0.211, P <0.01; r = 0.213, P <0.01; r = 0.233, P <0.01; r = 0.137, P <0.01). Logistic multivariate stepwise regression analysis showed that HbA_1c was an independent risk factor for CHD (OR = 1.436, 95% CI 1.128-1.828, P <0.01). Conclusion HbA 1c is positively correlated with the degree of coronary artery disease. Long-term increase may promote the occurrence of CHD.