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利用荧光雌激素及孕激素标记法观察了正常家兔及宫内放置铜丝、尼龙丝家兔一月后子宫内膜的雌、孕激素受体的荧光结合反应。结果,正常家兔子宫内膜雌、孕激素受体的荧光分布和含量随兔龄及生理周期而不同:增殖早期主要分布在上皮胞浆内;增殖晚期含量增加;分泌期间质细胞及血管亦有出现;妊娠早期主要在子宫内膜腔面。在胎盘滋养叶细胞中,孕激素受体荧光大大超过雌激素受体荧光。宫内放置铜丝后,增殖期子宫内膜的上皮细胞肿胀紧挤,细胞境界模糊,雌、孕激素受体荧光出现凝聚碎片或呈絮状,部分荧光消失,间质亦出现荧光反应。而宫内放置尼龙丝侧的变化甚少。提示铜离子可影响雌、孕激素受体蛋白。本文对铜离子在避孕机理中的意义进行了讨论。
Fluorescent estrogen and progesterone labeling method was used to observe the fluorescence-binding reaction of estrogen and progesterone receptor in endometrium of normal rabbits and intrauterine copper wires and nylon filament rabbits after one month. The results showed that the fluorescence distribution and content of estrogen and progesterone receptors in normal rabbits were different with the age of rabbits and their physiological cycles. The early proliferative phase mainly distributed in the epithelial cytoplasm, the late proliferative phase increased, and the secretion of stromal cells and blood vessels Have appeared; early pregnancy mainly in the endometrial cavity surface. In placental trophoblast cells, progesterone receptor fluorescence is significantly greater than that of estrogen receptor fluorescence. Intrauterine placement of copper wire, proliferative endometrial epithelial cells swollen tight squeeze, the cell boundary blur, estrogen and progesterone receptor fluorescence aggregated debris or flocculent, part of the fluorescence disappeared, the interstitial fluorescence reaction also appeared. The intrauterine placement of nylon filament changes little. Tip copper ions can affect estrogen and progesterone receptor protein. This article discusses the significance of copper ions in contraception.