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目的:研究血液系统恶性肿瘤患者的止凝血功能的变化情况,为其预后治疗提供依据。方法:本组抽取我院于2010年9月-2013年9月收治的血液系统恶性肿瘤患者43例作为观察组,取同期入院体检的正常人50例作为对照组,取血液标准行凝血功能检查。结果:分析两组患者止凝血功能指标的变化缓解期患者PLT、Fbg与对照组指标差异较为明显差异具有统计学意义(P<0.05)。分析对照组不同疾病周期的指标的变化,缓解期的患者PLT、Fbg明显高于进展期的患者,TT、aPTT、PT低于进展期患者,差异具有统计学意义(P<0.05)。结论:血液系统恶性肿瘤患者止凝血功能随着其病情的发展情况而不断变化,临床诊断期间,可将PLT、Fbg作为检查的特异性指标,并及时进行干预治疗。
Objective: To study the changes of hemostatic function in patients with hematological malignancies and provide basis for their prognosis. Methods: 43 cases of hematological malignancies admitted to our hospital from September 2010 to September 2013 were selected as the observation group, and 50 normal subjects admitted for the same period were taken as the control group. Blood samples were collected for coagulation tests . Results: The changes of coagulation index in the two groups were statistically significant (P <0.05). The PLT and Fbg in the remission group were significantly different from those in the control group (P <0.05). Analysis of the control group changes in different disease cycles, patients with remission PLT, Fbg was significantly higher than those in patients with advanced stage, TT, aPTT, PT was lower than that in patients with advanced stage, the difference was statistically significant (P <0.05). Conclusion: The hemostatic function of patients with hematological malignancies varies with the development of his condition. During the clinical diagnosis, PLT and Fbg may be used as the specific indexes for the examination and prompt intervention.