α- 2 b干扰素 ( IFN- α- 2 b)与拉米呋定联合治疗慢性乙型肝炎具有一定的 HBe Ag转阴率 ,本文作者将以往通常采用的 4～ 6个月疗程延长至 1 2个月 ,并从病毒学、血清酶学和肝组织活检等多方面观察干扰素联合拉米呋定与单独使用的疗效差异。　　作者选择 51例 1 8～ 6 0岁未经 α-2b interferon (IFN-α-2b) combined with lamivudine treatment of chronic hepatitis B has a negative rate of HBeAg, the authors of the past usually used 4 to 6 months of treatment extended to 1 2 months, and from the virology, serum enzymes and liver biopsy and other aspects of interferon combined lamivudine and single use of the difference in efficacy. The authors choose 51 cases 18 ~ 60 years old without