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通过冷冻铸造和热氧化法制备一种新型兼具抗菌功能和良好骨整合性能的纳米针状表面改性仿生多孔钛植入体。分析和表征仿生多孔钛植入体的孔隙形貌和尺寸、力学性能和体外成骨性能。结果表明:当控制冷冻铸造工艺中浆料中钛粉体积比为10%时,多孔试样的孔隙度为(58.32±1.08)%、孔径为(126.17±18.64)μm、压缩强度为(58.51±20.38)MPa、弹性模量为(1.70±0.52)GPa。在1200°C烧结1 h,多孔试样的孔隙度为(58.24±1.50)%、孔径为(124.16±13.64)μm、压缩强度为(54.77±27.55)MPa、弹性模量为(1.63±0.30)GPa。通过热氧化方法在多孔钛植入体试样的孔隙表面制备出均匀分布的纳米针状结构。通过对工艺的优化,制备出具有良好孔隙形貌和尺寸,同时具备良好力学性能和体外成骨性能的纳米针状表面改性仿生多孔钛植入体,具有重要的临床应用前景。
A novel nanometer acicular surface modified bionic porous titanium implant with both antibacterial function and good osseointegration performance was prepared by freeze-casting and thermal oxidation. The pore morphology and size, mechanical properties and in vitro osteogenesis of bionic porous titanium implants were analyzed and characterized. The results show that the porosity of the porous sample is (58.32 ± 1.08)%, the pore diameter is (126.17 ± 18.64) μm and the compressive strength is (58.51 ± 20.38) MPa, and the elastic modulus was (1.70 ± 0.52) GPa. The porosity of the porous sample was (58.24 ± 1.50)%, the average pore size was (124.16 ± 13.64) μm, the compressive strength was 54.77 ± 27.55 MPa and the elastic modulus was 1.63 ± 0.30 after sintering at 1200 ° C for 1 h. GPa. A uniform distribution of nanostructured acicular structures was prepared on the porous surface of the porous titanium implant by thermal oxidation. Through the optimization of the process, nanometer needle-shaped surface modified bionic porous titanium implants with good pore morphology and size, good mechanical properties and in vitro osteogenesis properties are prepared, which has an important clinical application prospect.