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目的探讨观察α-硫辛酸联合前列地尔治疗2型糖尿病周围神经病变的临床疗效。方法 60例2型糖尿病周围神经病变患者,随机分配法将患者分为对照组和观察组,每组30例。对照组患者以药物α-硫辛酸进行治疗;观察组患者在对照组基础上联合前列地尔进行治疗,比较两组患者的治疗效果。结果观察组总有效率为86.7%,高于对照组的63.3%,差异具有统计学意义(P<0.05)。观察组治疗后的空腹血糖及糖化血红蛋白水平分别为(6.2±0.3)mmo L/L、(6.8±3.2)%,明显优于对照组的(7.1±0.4)mmo L/L、(7.6±0.6)%,差异均具有统计学意义(P<0.05)。结论α-硫辛酸联合前列地尔治疗2型糖尿病周围神经病变临床效果显著,可在临床上进行推广使用。
Objective To investigate the clinical efficacy of α-lipoic acid combined with alprostadil in the treatment of type 2 diabetic peripheral neuropathy. Methods Sixty patients with type 2 diabetic peripheral neuropathy were randomly divided into control group and observation group with 30 cases in each group. Patients in the control group were treated with α-lipoic acid. Patients in the observation group were treated with alprostadil on the basis of the control group, and the treatment effect was compared between the two groups. Results The total effective rate in observation group was 86.7%, which was higher than that in control group (63.3%), the difference was statistically significant (P <0.05). The levels of fasting blood glucose and glycosylated hemoglobin in the observation group were (6.2 ± 0.3) mmo L / L and (6.8 ± 3.2)%, respectively, which were significantly better than those in the control group (7.1 ± 0.4) mmo L / L and 7.6 ± 0.6 )%, The differences were statistically significant (P <0.05). Conclusion α-lipoic acid combined with alprostadil treatment of type 2 diabetic peripheral neuropathy has a significant clinical effect, which can be widely used in clinical practice.