利用 3 -氯 4-氰基 5 -异噻唑肼与各种芳基异氰酸酯反应 ,合成了未见文献报道的 1-( 3 -氯 4-氰基 5 -异噻唑氨基 ) 3 -芳基脲 ,产物经元素分析、核磁共振和红外光谱表征。研究表明反应与芳基异氰酸酯上苯环所连的取代基有关 ,吸电子基有利于反应速度的提高 ,这与此反应属亲核加成反应机理是一致的。企图利用芳基异硫氰酸酯与 3 -氯 4-氰基5 -异噻唑肼反应合成类似结构的芳基硫脲未获成功 A novel 3 - chloro - 4 - cyano 5 - isothiazole amino group was synthesized by the reaction of 3 - chloro 4 - cyano 5 - isothiazole hydrazide with various aryl isocyanates. The product was characterized by elemental analysis, nuclear magnetic resonance and infrared spectroscopy. The research shows that the reaction is related to the substituents attached to the phenyl ring of the aryl isocyanate, and the electron-withdrawing group is favorable to the improvement of the reaction rate, which is consistent with the mechanism of this nucleophilic addition reaction. Attempts to synthesize arylthioureas of similar structure by aryl isothiocyanate and 3 - chloro 4 - cyano 5 - isothiazole hydrazine were unsuccessful