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[目的]观察消渴康颗粒联合二甲双胍治疗2型糖尿病疗效。[方法]使用随机平行对照方法,将116例住院及门诊患者按掷骰子方法简单随机分为两组。对照组58例二甲双胍,0.25g/次,2~3次/d,餐后即服。治疗组58例消渴康颗粒,9g/次,3次/d,餐前温水送服;西药治疗同对照组。连续治疗30 d为1疗程。观测临床症状、空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、胰岛β细胞功能指数(HOMA-β)、不良反应。连续治疗2疗程(60d),判定疗效。[结果]治疗组显效31例,有效24例,无效3例,总有效率94.83%;对照组显效20例,有效22例,无效16例,总有效率72.41%;治疗组疗效优于对照组(P<0.01)。FPG、2hPG、HbA1c、HOMA-β两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]消渴康颗粒联合二甲双胍治疗2型糖尿病,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Xiaokekang granule combined with metformin on type 2 diabetes mellitus. [Methods] Using randomized parallel control method, 116 inpatients and outpatients were randomly divided into two groups randomly according to the dice method. Control group, 58 cases of metformin, 0.25g / time, 2 to 3 times / d, that is, after meals. 58 cases in the treatment group Xiaokekang granules, 9g / time, 3 times / d, warm water before delivery; western medicine treatment with the control group. Continuous treatment of 30 d for a course of treatment. Clinical symptoms, fasting blood glucose (FPG), postprandial 2h blood glucose (2hPG), HbA1c, HOMA-β, and adverse reactions were observed. Continuous treatment of 2 courses (60d), determine the efficacy. [Results] In the treatment group, 31 cases were markedly effective, 24 cases were effective, 3 cases were ineffective, and the total effective rate was 94.83%. In the control group, 20 cases were markedly effective, 22 cases were effective and 16 cases were ineffective. The total effective rate was 72.41% (P <0.01). The levels of FPG, 2hPG, HbA1c and HOMA-β were improved in both groups (P <0.01). The treatment group improved more than the control group (P <0.01). [Conclusion] Xiaokekang granule combined with metformin in the treatment of type 2 diabetes mellitus has satisfactory curative effect and no serious adverse reactions, which deserves promotion.