通过对人肝组织中1型血管紧张素Ⅱ受体(AT1R)的检测,探讨肝纤维化形成过程中AT1R的表达变化以及它在肝纤维化发生发展中可能的作用。 1.材料与方法:(1)标本来源:12例正常肝组织均取自尸体供肝(热缺血时间约3 min),18例纤维化肝组织取自广州军区总医院肝胆外科新鲜手术切除标本,其中10例为原发性肝癌周围组织,8例为硬化肝组织。30例中男性20例,女性10例,年 Through the detection of type 1 angiotensin Ⅱ receptor (AT1R) in human liver tissue, the expression of AT1R in hepatic fibrosis and its possible role in the development of hepatic fibrosis were explored. 1. Materials and Methods: (1) Specimen Source: 12 cases of normal liver tissue were taken from the cadaveric liver (warm ischemia time of about 3 min), 18 cases of fibrotic liver tissue taken from the Guangzhou Military Region General Hospital of hepatobiliary surgery fresh surgical resection Specimens, of which 10 cases of primary liver cancer around the organization, 8 cases of cirrhotic liver tissue. 30 cases of 20 males and 10 females, year