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目的:研究小儿咳喘颗粒抗炎作用并初步探讨其作用机制。方法:采用大鼠足跖皮下注射角叉菜胶致急性炎症模型,观察小儿咳喘颗粒对致炎后大鼠足肿胀的影响;采用气管内滴入脂多糖诱导小鼠急性肺损伤,观察药物对小鼠肺组织TNF-α、IL-10含量的影响。结果:小儿咳喘颗粒在多个时间点均可减轻大鼠足肿胀;并明显降低ALI小鼠TNF-α水平(P<0.01),可增加模型小鼠肺组织匀浆中IL-10含量。结论:小儿咳喘颗粒有明显的抗炎作用,对急性肺损伤有一定的保护作用。
Objective: To study the anti-inflammatory effects of Xiaoke Kechuan Granules and to explore its mechanism. METHODS: Acute inflammation model was induced by subcutaneous injection of carrageenan in rats. The effect of Xiaoke Kechuan Granule on foot swelling of rats after inflammation was observed. Intratracheal instillation of lipopolysaccharide was used to induce acute lung injury in mice. Effects of TNF-α, IL-10 in lung tissue of mice. Results: Pediatric Kechuan granules could reduce paw edema in rats at various time points, and significantly reduce TNF-α levels in ALI mice (P<0.01). It can increase IL-10 content in lung homogenate of model mice. Conclusion: Pediatric Kechuan Granule has obvious anti-inflammatory effects and has a certain protective effect on acute lung injury.