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目的研究鹰嘴豆芽素A对高脂血症大鼠的降血脂作用。方法健康雄性SD大鼠60只,三月龄,随机分为正常组、模型组、血脂康组、鹰嘴豆芽素A低、中、高剂量组,每组10只。除正常组给予普通饲料外,其他5组灌胃给予10 mL/(kg.d)高脂乳剂,一周后,在每天灌胃高脂乳剂的基础上,血脂康组灌胃0.1 g/(kg.d)的血脂康;鹰嘴豆芽素A低、中和高剂量组分别灌胃0.3,0.6和1.2 g/(kg.d)鹰嘴豆芽素,给药30 d后测定血总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平、全血黏度和血浆黏度;凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)和纤维蛋白原含量(FIB)。结果鹰嘴豆芽素A能明显降低TC、TG和LDL-C水平及升高HDL-C水平(P<0.05),显著降低全血黏度和血浆黏度(P<0.05),同时能显著性延长PT、APTT及降低FIB(P<0.05)。结论鹰嘴豆芽素A能降低高脂血症大鼠的血脂水平、血液黏度及FIB,改善血液循环,抑制因血脂升高和脂质代谢紊乱引起的血液凝血系统指标的改变。
Objective To study the hypolipidemic effects of chickpea sp. A on hyperlipidemic rats. Methods Sixty healthy male SD rats were randomly divided into normal group, model group, Xuezhikang group and chickpea splenicin A low, medium and high dose group, with 10 rats in each group. In addition to the normal group given ordinary feed, the other five groups were given 10 mL / (kg.d) high fat emulsion by gavage. One week later, on the basis of daily high fat emulsion, Xuezhikang group was fed with 0.1 g / (kg) .d) Xuezhikang; chickpea sp. A low, middle and high dose group were fed 0.3, 0.6 and 1.2 g / (kg.d) of chickpea sp., after administration for 30 days, blood total cholesterol TG, LDL-C and HDL-C, whole blood viscosity and plasma viscosity, prothrombin time (PT), activated partial thrombosis Live enzyme time (APTT), thrombin time (TT) and fibrinogen content (FIB). Results The results showed that chickpea sp. A significantly decreased TC, TG and LDL-C levels and increased HDL-C level (P <0.05), while significantly decreased whole blood viscosity and plasma viscosity (P <0.05) , APTT and decreased FIB (P <0.05). Conclusions Chickpea splenic A can reduce blood lipid, blood viscosity and FIB in hyperlipidemic rats, improve blood circulation, and restrain the changes of blood coagulation system indexes caused by hyperlipidemia and lipid metabolism disorder.