【摘 要】
:
Anti-B cell maturation antigen(BCMA)chimeric antigen receptor(CAR)T-cell therapyis effective and well-tolerated for refractory or relapsed multiple myeloma(RRMM).The purposcof the present study was to analyze efficacy in RRMM patients with renal impairmen
【机 构】
:
DepartmentofHematology,ThirdHospitalofShanxiMedicalUniversity
【基金项目】
:
the National Natural Science Foundation of China(No.81873452),the Clinical Research Program of Huazhong University of Science and Technology Affiliated Tongji Hospital(No.2020003).
论文部分内容阅读
Anti-B cell maturation antigen(BCMA)chimeric antigen receptor(CAR)T-cell therapyis effective and well-tolerated for refractory or relapsed multiple myeloma(RRMM).The purposcof the present study was to analyze efficacy in RRMM patients with renal impairmen
其他文献
目的:通过对静脉药物配置中心(PIVAS)不合理医嘱进行分析,为临床合理用药提供参考.方法:以2020年提交PIVAS审核的医嘱作为研究对象,分析不合理用药情况.结果:2020年1—12月提
目的总结误诊为宫内孕的宫颈妊娠病例临床与超声影像学特征,以提高临床医师对宫颈妊娠早期诊断的能力。方法回顾性分析2010年1月至2019年12月期间首都医科大学附属北京妇产医院生殖调节/计划生育科收治的11例误诊为宫内孕的宫颈妊娠患者生育史、专科查体、误诊前后的超声影像学特征及治疗结局。结果11例病例中已育者7例,其中有剖宫产史6例;9例有流产刮宫术史;误诊为宫内早孕6例,误诊为稽留流产3例,误诊为
Chronic stress plays a critical role in the etiology of sporadic Alzheimers disease(AD).However,there are currently no effective drugs that can target chronic stress to prevent AD.In this study,we explored the neuroprotective effect of hydroxysafflor ye
We performed a retrospective analysis to investigate dynamic peri-hematopoietic stem cell transplantation(HSCT)minimal/measurable residual disease(MRD)on outcom
目的:建立清热散结制剂的近红外一致性模型,为鉴别不同厂家的产品提供依据。方法:使用MPA型近红外光谱仪(1.5 m光纤探头)、OPUS 5.5软件,对全部批次样品进行了原始光谱扫描,并对其进行矢量归一化及一阶导数等数学处理方法。结果:将平滑点数及一致性指数(CI值)设置为不同数值后,所建模型均能将不同厂家的清热散结制剂快速筛分及鉴别,且各模型经验证均可行。结论:通过对该品种近红外一致性模型的建立,为更好地快筛不同厂家清热散结制剂提供了科学准确的检验检测方法。
Recent studies indicated that regulatory B cells(Bregs)and nuclear factor erythroid 2-related factor 2(Nrf2)antioxidant signaling pathway play important roles in the pathogenesis of chronic graft-versus-host disease(cGVHD).Mangiferin(MA),a polyphenol comp
Superoxide dismutase 2(SOD2)-mediated gene therapy has significant protective effects against kanamycin-induced hearing loss and hair cell loss in the inner ear,but the underlying mechanisms are still unclear.Herein,an in vivo aging model of mitochondrial
目的:建立HPLC法测定妇康宝口服液中阿魏酸含量的方法。方法:色谱柱为phenomenex Luna C18(2)100?魡(250 mm×4.6 mm,5μm)色谱柱,流动相为乙腈-0.1%磷酸水溶液体系梯度洗脱,流速为1.0 ml/min,检测波长为321 nm,柱温为35℃。结果:阿魏酸在1.5890~10.5930μg/ml浓度范围内呈现良好线性(r=1.0000),精密度(RSD为1.7%)和重复性(RSD为1.1%)良好,在24 h内稳定性良好(RSD为1.8%),加样回收率平均值为97.13
目的:建立电感耦合等离子体质谱(ICP-MS)法测定甲基纤维素中8种元素(铅、砷、汞、镉、钒、硒、钴、钼)的含量。方法:甲基纤维素样品经微波消解后,采用电感耦合等离子体质谱同时测定上述8种元素的含量,并进行了方法学考查。结果:3个厂家10批样品的元素含量均符合要求。8种元素在各自的浓度范围内具有良好的线性关系(r均大于0.999),精密度试验的RSD为0.65%~1.8%,平均回收率为93.7%~104.2%。结论:该方法结果准确,灵敏度高,具有良好的重现性,适用于测定甲基纤维素中8种元素的含量。
The role of B7-1 in podocyte injury has received increasing attention.The aim of this study was to investigate whether losartan protects podocytes of patients with diabetic kidney disease(DKD)by regulating B7-1 and the underlying mechanisms.Rats with stre