目的　探讨巨大型垂体腺瘤切除手术中的垂体柄保护。方法　采用经纵裂蝶窦入路显微手术切除巨大型垂体腺瘤 5 2例。结果　肿瘤全切除 39例 (75 % )。垂体柄保留 34例 (6 5 % )。术后发生尿崩 32例 (6 2 % ) ,其中 2 3例在术后 1～ 2周内恢复正常 ,占术后尿崩总数的 72 % ;7例在 3个月内恢复 ;2例尿崩症状持续 1年以上。结论　垂体腺瘤手术中的垂体柄保留可有效降低术后尿崩症 ,特别是永久性尿崩症的发生 ,是提高手术效果的重要措施 Objective To explore the pituitary stalk protection during the resection of huge pituitary adenoma. Methods A total of 52 cases of giant pituitary adenomas were excised by microsurgical approach to the sphenoid sinus. Results Total tumor resection in 39 cases (75%). Pituitary stalk retained 34 cases (65%). 32 cases (62%) had postoperative diabetes insipidus, of which 23 cases returned to normal within 1-2 weeks after operation, accounting for 72% of the total number of postoperative diabetes insipidus; 7 cases recovered within 3 months; 2 cases of urine Collapse symptoms last more than 1 year. Conclusion The preservation of pituitary stalk during pituitary adenoma surgery can effectively reduce postoperative diabetes insipidus, especially permanent diabetes insipidus, which is an important measure to improve the operative effect