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目的 :旨在了解枢丹 (盐酸昂丹司琼 )在消化道肿瘤病人接受化疗期间的止呕疗效及其不良反应。材料和方法 :78例消化道肿瘤并接受化疗的病人 ,连续观察 2个疗程 ,以胃复安 (甲氧氯普胺 )作为对照组 ,化疗方案包括动脉插管化疗、腹腔化疗、静脉化疗 ,恶心呕吐分级采用WHO标准 ,临床有效以完全缓解和部分缓解计算。结果 :3种不同化疗途径枢丹的总有效率为 86 .0 2 % ,与对照组相比有显著差异 (P <0 .0 0 1) ;无论何种化疗途径枢丹A、B两组间无差异 ;化疗过程中呕吐发生率枢丹组明显低于对照组 (P <0 .0 5 ) ;枢丹最常见的不良反应为便秘 ,其次是头痛头晕、腹痛腹泻等 ,大多可自行缓解。结论 :枢丹在消化道肿瘤病人化疗过程中有较强的止呕作用 ,不良反应较小。
OBJECTIVE: To understand the curative effect and adverse reactions of dandruff (ondansetron hydrochloride) in patients with digestive tract cancer during chemotherapy. MATERIAL AND METHODS: A total of 78 patients with digestive tract tumors undergoing chemotherapy were enrolled in the study. Patients were followed up for 2 courses of treatment with metoclopramide (metoclopramide) as a control group. The chemotherapy regimens included arterial intubation chemotherapy, intraperitoneal chemotherapy, intravenous chemotherapy, Nausea and vomiting grading using WHO standards, clinically effective to complete remission and partial remission calculations. Results: The total effective rate of three different chemotherapy regimens was 86.02%, which was significantly different from that of the control group (P <0.01). No difference was found between the two groups The incidence of vomiting during chemotherapy was significantly lower in the Shu Dan group than in the control group (P <0.05). The most common adverse drug reactions were constipation, followed by headache and dizziness, abdominal pain and diarrhea, most of which could be relieved spontaneously . Conclusion: Puberty has a strong antiemetic effect in patients with gastrointestinal cancer during chemotherapy, with less adverse reactions.