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以苯甲酸、水杨酸、甲硝唑为模型药物,对猪耳和猪腹部皮肤进行体外药物渗透实验,在相同条件下与正常人体皮肤进行了渗透性差别的比较研究。结果表明:猪耳和猪腹部皮肤与人体皮肤对药物渗透性具有相似性,特别是猪耳皮肤对药物体外透皮实验是个有价值的动物模型。
Using benzoic acid, salicylic acid and metronidazole as model drugs, the in vitro drug permeation experiments were performed on the pig’s ear and pig’s abdomen skin, and compared with the normal human skin under the same conditions. The results showed that the skin permeability of pig and pig skin was similar to that of human skin, especially pig skin was a valuable animal model for in vitro transdermal drug delivery.