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痛性周围神经病以神经病理性疼痛为突出表现,可伴运动、感觉及自主神经功能异常,主要累及小纤维(Aδ和C纤维),根据病因可以分为遗传性和获得性。可为独立性疾病亦可为其他疾病表现的一部分,前者指特发性小纤维神经病。疼痛包括自发性和诱发性疼痛,表现为长度依赖性,呈现“手套袜套”样分布。痛性周围神经病的主要辅助检查包括定量感觉检测、表皮内神经纤维密度、皮肤交感反应等。治疗原发病和控制疼痛是主要治疗手段,常用药物包括卡马西平、普瑞巴林、阿米替林等。
Painful peripheral neuropathy with neuropathic pain as a prominent manifestation may be associated with motor, sensory and autonomic dysfunction, mainly involving small fibers (Aδ and C fibers), according to the cause can be divided into genetic and acquired. Can be independent disease can also be part of the performance of other diseases, the former refers to idiopathic small fiber neuropathy. Pain includes both spontaneous and induced pain, manifested as length dependence, showing “glove socks” like distribution. The main auxiliary examinations of painful peripheral neuropathy include quantitative sensory testing, intraepidermal nerve fiber density, skin sympathetic response, and the like. Treatment of primary disease and control of pain is the main treatment, commonly used drugs, including carbamazepine, pregabalin, amitriptyline and so on.