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目的:研究民族药蔓菁的在体抗菌、抗病毒作用,进而揭示其治疗“肺燥咳嗽”的机制。方法:按照传统方法制备蔓菁膏,观察其低、中、高3个剂量[剂量分别为250、500、1000 mg(浸膏)·(kg·d)-1]对金黄色葡萄球菌、肺炎链球菌、流感病毒感染致小鼠死亡及肺指数的影响。结果:蔓菁膏3个剂量对金黄色葡萄球菌感染小鼠均没有明显的保护作用,但对小鼠小肠炎性病变具有一定的缓解作用;蔓菁膏3个剂量均可降低肺炎链球菌致小鼠感染死亡率(由90%降至15%~30%),中剂量效果最佳(死亡率为15%);蔓菁膏低、高剂量还能减轻流感病毒性小鼠肺炎的充血水肿实变并降低肺指数,其肺指数抑制率分别为29.23%、28.38%,低剂量效果最佳,中剂量没有明显的作用。结论:蔓菁膏对肺炎链球菌和流感病毒感染小鼠具有保护作用,量效关系不成线性,为其临床应用于治疗“肺燥咳嗽”提供参考。
Objective: To study the antimicrobial and antiviral effects of Chinese medicinal herb Manjing in vivo and to reveal the mechanism of its treatment of “dry cough of lung”. Methods: According to the traditional method, we prepared the red, medium and high doses of vine manure (250, 500 and 1000 mg · kg -1) respectively against Staphylococcus aureus and pneumonia Streptococcus, influenza virus infection in mice death and lung index. Results: There was no obvious protective effect of all the three doses of Manjing cream on mice infected with Staphylococcus aureus, but it could relieve the inflammation of small intestine in mice. Mice infected with the mortality rate (from 90% to 15% to 30%), the best results in the middle dose (mortality rate was 15%); vinegar extract low, high doses can reduce influenza virus pneumonia in mice congestion and edema Consolidation and reduce the lung index, the lung index inhibition rates were 29.23%, 28.38%, the best effect of low doses, no significant role in the dose. CONCLUSION: Mung Extract has a protective effect against S. pneumoniae and influenza virus infection in mice, and its dose-response relationship is not linear. It provides a reference for its clinical application in the treatment of “Dry cough”.