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本实验选用６０只雄性大鼠，体重３００ｇ～４００ｇ，随机分为３组：①对照组；②缺血３０分钟再灌流６０分钟组；③治疗组。每组各２０只。通过制备大鼠脑缺血再灌流模型，测定各组脑组织中丙二醛及超氧化物歧化酶的含量，并结合电镜观察。结果显示，缺血再灌流组丙二醛含量高于对照组（Ｐ＜０．０１），而超氧化物歧化酶低于正常组（Ｐ＜０．０１），同时电镜观察显示脑组织水肿及退行性改变。应用尼莫地平治疗则能明显减轻上述改变，对脑缺血再灌流损伤有保护作用。
In this experiment, 60 male rats weighing 300g ~ 400g were randomly divided into three groups: ① control group; ② ischemia-reperfusion 30-minute reperfusion for 60 minutes; ③ treatment group. Each group of 20. The rat model of cerebral ischemia and reperfusion was established. The contents of malondialdehyde (MDA) and superoxide dismutase (SOD) in brain tissue of each group were determined and observed by electron microscope. The results showed that the content of malondialdehyde in ischemic reperfusion group was higher than that in control group (P <0.01), but superoxide dismutase was lower than that in normal group (P <0.01) Degenerative changes. Nimodipine treatment can significantly reduce the above changes, cerebral ischemia and reperfusion injury has a protective effect.