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目的:探究血清视黄醇结合蛋白联合胱抑素C对妊娠期糖尿病早期肾病(DN)的诊断价值。方法:选取2009年2月~2014年4月在一汽总医院待产的妊娠期糖尿病患者102例,根据24 h尿白蛋白排泄量(UAER)分为单纯糖尿病组(UAER<30 mg/24 h)36例、早期DN组(30 mg/24 h300 mg/24 h)32例,并随机选取同期来医院进行孕期体检的健康孕妇50例作为对照组,检测4组病例的血清视黄醇结合蛋白(RBP)和血清胱抑素C(Cys-C)水平。结果:单纯糖尿病组的RBP和Cys-C水平同对照组相比差异无统计学意义(P>0.05);早期DN组和临床DN组其RBP和Cys-C水平均明显高于对照组,差异有统计学意义(P<0.05),且随着病情的发展RBP和Cys-C水平会不断升高。Cys-C、RBP联合检测的灵敏度为91.18%,其敏感程度明显高于单一检测。结论:血清视黄醇结合蛋白、胱抑素C联合检测在诊断妊娠期糖尿病早期肾病上具有更高的灵敏度,以便及时对处于妊娠期的患者进行预防和治疗,减少相关并发症的出现。
Objective: To investigate the diagnostic value of serum retinol binding protein combined with cystatin C in gestational diabetic nephropathy (DN). Methods: A total of 102 gestational diabetes patients were enrolled in FAW General Hospital from February 2009 to April 2014. UAER was divided into two groups according to 24-hour urinary albumin excretion (UAER <30 mg / 24 h) Thirty-six patients were randomly divided into control group (n = 36), early DN group (34 patients with 30 mg / 24 h <300 mg / 24 h and UAER> 300 mg / 24 h) Fifty pregnant women were used as control group to detect serum retinol binding protein (RBP) and serum cystatin C (Cys-C) levels in four groups. Results: The RBP and Cys-C levels in diabetic group were not significantly different from those in control group (P> 0.05). The levels of RBP and Cys-C in DN group and DN group were significantly higher than those in control group (P <0.05), and with the development of the disease RBP and Cys-C levels will continue to rise. The sensitivity of Cys-C, RBP combined detection was 91.18%, which was significantly higher than that of single detection. Conclusion: Serum retinol binding protein, cystatin C combined detection of early diagnosis of gestational diabetes early kidney disease with higher sensitivity in order to timely prevention and treatment of patients in pregnancy, reduce the occurrence of complications.