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目的对比分析应用植入性缓释氟尿嘧啶同步放化疗与顺铂方案同步放化疗治疗中晚期宫颈癌患者的疗效与毒副作用。方法选择2013年1月-2014年7月在新疆医科大学附属肿瘤医院收治的初治宫颈癌患者共80例,临床分期为Ⅱb~Ⅲb期,按治疗方法不同分试验组40例(氟尿嘧啶瘤内植入区域化疗配合根治性放疗组),对照组40例(顺铂静脉周疗配合根治性放疗组)。对两组患者的近期疗效及毒副反应进行对比分析。结果试验组CR为22例,PR为13例,NC和PD为5例。对照组CR为19例,PR为14例,NC和PD为7例。试验组和对照组有效率分别为88%(35/40)、83%(32/40),两组比较差异无统计学意义。3级以上的急性反应中,试验组出现骨髓抑制6例,消化道反应3例;对照组出现骨髓抑制17例,消化道反应5例,两组间骨髓抑制差异有统计学意义(P<0.05)。结论植入性缓释氟尿嘧啶同步放化疗与顺铂周疗疗效相当,毒副反应较小。
Objective To compare and analyze the curative effect and side effects of concurrent chemoradiotherapy with cisplatin in patients with advanced cervical cancer treated by implantable sustained-release fluorouracil and concurrent cisplatin. Methods From January 2013 to July 2014, 80 patients with newly diagnosed cervical cancer admitted to Cancer Hospital of Xinjiang Medical University were enrolled. The clinical stage was stage Ⅱb-Ⅲb. According to the different treatment groups, 40 cases were treated with fluorouracil In combination with radical radiotherapy, the control group received 40 cases of cisplatin intravenous chemotherapy combined with radical radiotherapy. The two groups of patients with short-term efficacy and toxicity were compared. Results The experimental group CR was 22 cases, PR was 13 cases, NC and PD were 5 cases. The control group CR was 19 cases, PR was 14 cases, NC and PD were 7 cases. The experimental group and control group were 88% (35/40) and 83% (32/40) respectively, with no significant difference between the two groups. There were 6 cases of myelosuppression and 3 cases of digestive tract reaction in test group, 17 cases of bone marrow suppression and 5 cases of gastrointestinal reaction in the control group. There was significant difference in bone marrow suppression between the two groups (P <0.05) ). Conclusions Simultaneous chemoradiation with sustained-release fluorouracil is more effective than cisplatin in peripheral radiotherapy, with less toxic and side effects.