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目的探讨生促红素人肝细胞2(EphA2)、上皮型钙黏附蛋白(E-cad)和血管内皮生长因子(VEGF)在非小细胞肺癌(NSCLC)中的表达及其与临床病理特征的关系。方法用免疫组织化学Envision法检测62例NSCLC中EphA2、E-cad和VEGF的表达。结果 EphA2的阳性表达率与有淋巴结转移、临床分期、5年生存率有关(P<0.05),E-cad的异常表达率与有淋巴结转移、临床分期和5年生存率有关(P<0.01),VEGF的过表达与有淋巴结转移、临床分期有关(P<0.01)。EphA2与E-cad的表达呈负相关(P<0.01)。结论在NSCLC中EphA2和VEGF的过表达及E-cad的低表达与肿瘤的淋巴结转移、临床分期有关,EphA2、E-cad的异常表达与术后生存时间有关,可作为判断NSCLC预后的指标。
Objective To investigate the expression of EphA2, E-cad and VEGF in non-small cell lung cancer (NSCLC) and its relationship with clinicopathological features . Methods Envision method was used to detect the expression of EphA2, E-cad and VEGF in 62 cases of NSCLC. Results The positive expression rate of EphA2 was correlated with lymph node metastasis, clinical stage and 5-year survival rate (P <0.05). The abnormal expression of E-cad was correlated with lymph node metastasis, clinical stage and 5-year survival rate The overexpression of VEGF correlated with lymph node metastasis and clinical stage (P <0.01). EphA2 and E-cad expression was negatively correlated (P <0.01). Conclusion The overexpression of EphA2 and VEGF and the low expression of E-cad in NSCLC are correlated with the lymph node metastasis and clinical stage of NSCLC. The abnormal expression of EphA2 and E-cad may be related to the survival time of NSCLC.