1984～1988年在海南岛西部和南部地区就恶性疟喹哌的敏感性进行观察,用磷酸喹哌标准疗程治疗恶性疟患者,追踪观察167例。结果表明,1986年这些地区都发现了一级抗性病例,但80～90％仍属敏感。1988年,东方、三亚两地抗性的比例和抗性程度都显著增加,是目前海南岛疟疾防治工作必须高度重视和急待解决的问题。 From 1984 to 1988, the susceptibility of falciparum to falciparum in western and southern part of Hainan Island was observed, and 167 cases were treated with standard course of Quipfosiperidyl for the treatment of falciparum malaria. The results show that in 1986 these areas were found in the case of first-class resistance, but 80 to 90% are still sensitive. In 1988, there was a marked increase in the proportion of resistance and the degree of resistance in the East and Sanya areas. This is a problem that must be paid great attention to and an urgent solution to malaria prevention and control work in Hainan Island at present.