硫喷妥钠(TP)为常用的静脉诱导药,经验表明,TP的最小诱导剂量(MID)受很多因素影响。当TP用量过多时,常可导致严重的呼吸循环抑制。为了能正确地估计病人所需TP的MID,切实做到用药剂量个体化,许多学者对这一问题进行了探讨,现综述如下。体型和体重就药理学观点来看,体重应分两种:(1)解剖学体重或机体体重(BW),即人体总重量;(2)药理学体重或活性体重(ABM), Thiopental (TP) is a commonly used intravenous drug. Experience has shown that the minimum induction dose (MID) of TP is affected by many factors. When the amount of TP is excessive, can often lead to severe respiratory cycle inhibition. In order to correctly estimate the patient’s TP required for the MID, the effective dose of individualized, many scholars have discussed this issue, are summarized below. Body Size and Weight From a pharmacological point of view, weight should be divided into two categories: (1) anatomical body weight or body weight (BW), ie, total body weight; (2) pharmacological weight or active body weight (ABM)