胃肠道间质瘤( GIST)是消化道最常见的间叶源性肿瘤，可以发生在胃、小肠、食管、结直肠以及肠系膜、肝等胃肠道外组织。 GIST与Kit基因及血小板衍生生长因子受体基因的突变有关，临床实践证实，甲磺酸伊马替尼对其有治疗效果。 GIST多与其他肿瘤并发，大部分是在胆囊切除手术及胃癌、食管癌、肠癌等的根治手术中被发现。该文将与癌并发的GIST的临床病理学特征及研究现状予以综述。“,”Gastrointestinal stromal tumor( GIST) is the most common digestive tract lobus intermedius tumor,which may occur in the stomach,small intestine,esophagus,colorectal and gastrointestinal tract organs as mesentery and liver. GIST is associated with Kit gene and PDGFRA gene. Clinical practice showed that, imatinib mesylate had effect on GIST. GIST is often complicating with other tumors,mianly found in gallblad-der removal operation and radical operations for gastric cancer,esophageal cancer,colorectal cancer. Here is to make a review of the clinical pathological characteristics and research status of GIST.