目前,原发性肿瘤骨转移的显像方面属放射性核素扫描最为敏感.70年代初期,由于~(99m)Tc 的出现,在放射性核素骨扫描方面出现了突破.~(99m)Tc 并不发射β射线,半衰期仅6小时,辐射剂量低,用~(99m)Tc 标记的各种化合物中,二磷酸盐类最易从血池中被清除掉。由于血液及骨外组织中放射性低,改善了图像及提高了诊断的正确性.锝标记的二磷酸盐是由化学吸附而进入骨的主要晶体-羟基磷灰石的磷酸基团上. At present, the imaging of primary tumor bone metastasis is most sensitive to radionuclide scanning.In the early 1970s, there was a breakthrough in the radionuclide bone scan due to the appearance of ~ (99m) Tc. No emission of beta rays, half-life of only 6 hours, low radiation dose, with ~ (99m) Tc labeled compounds in various, diphosphate is the most easily removed from the blood pool. Due to the low radioactivity in the blood and extranodal tissue, the images are improved and the diagnostic accuracy is improved. Technetium labeled diphosphates are chemisorbed onto the phosphate group of hydroxyapatite, the primary crystal of bone.