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目的:认识和分析BMP及其受体与口腔鳞癌发生、发展的可能关系。方法:用免疫组织化学、原位杂交方法分析BMP-2/4、-5及Ⅰ、Ⅱ型BMP受体在Tca8113细胞中的表达及意义。结果:BMP-2/4、-5及Ⅰ、Ⅱ型BMP受体在Tca8113细胞中有表达。其中,在细胞胞浆中发现有BMP-2/4、-5的阳性信号及有Ⅰ、Ⅱ型BMP受体的强阳性表达。结论:BMP及其受体与口胺鳞癌发生、发展有密切关系。
Objective: To understand and analyze the possible relationship between BMP and its receptor and the occurrence and development of oral squamous cell carcinoma. Methods: The expressions of BMP-2/4, -5 and type I and type II BMP receptors in Tca8113 cells were detected by immunohistochemistry and in situ hybridization. Results: BMP-2/4, -5 and type I and type II BMP receptors were expressed in Tca8113 cells. Among them, positive signals of BMP-2/4 and -5 were found in the cytoplasm of cells and strongly positive expressions of type I and II BMP receptors. Conclusion: BMP and its receptor are closely related to the occurrence and development of oral squamous cell carcinoma.