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目的:探讨硫酸乙酰肝素蛋白聚糖-1在卵巢癌中的表达及其与预后的关系,为卵巢癌临床病情的判断和预后的评估提供参考。方法:回顾性分析198例卵巢癌患者的临床资料。通过检测所有标本的硫酸乙酰肝素蛋白聚糖-1的表达情况,并结合患者的临床资料,分析硫酸乙酰肝素蛋白聚糖-1的表达与患者预后的关系。结果:卵巢癌的组织学类型以浆液型为主,83.33%的黏液型卵巢癌和透明细胞型卵巢癌的肿瘤上皮细胞硫酸乙酰肝素蛋白聚糖-1表达为阳性,均显著高于其他类型卵巢癌(P<0.05)。分化程度低的卵巢癌其间质细胞硫酸乙酰肝素蛋白聚糖-1表达阳性率显著上升(P<0.05)。肿瘤上皮细胞硫酸乙酰肝素蛋白聚糖-1表达阳性患者的生存时间显著短于硫酸乙酰肝素蛋白聚糖-1表达阴性的患者(P<0.05);间质细胞硫酸乙酰肝素蛋白聚糖-1的表达与患者的预后相关(P<0.05)。Cox比例风险模型分析显示,患者的FIGO分期、肿瘤组织学分级、肿瘤组织学类型、硫酸乙酰肝素蛋白聚糖-1的表达与患者的预后相关(P<0.05)。结论:硫酸乙酰肝素蛋白聚糖-1表达阳性可能与卵巢癌的发生、浸润及其转移有关,对卵巢癌患者预后不良有一定的预测价值。
Objective: To investigate the expression of heparan sulfate proteoglycan-1 in ovarian cancer and its relationship with prognosis, and to provide a reference for judging the prognosis and prognosis of ovarian cancer. Methods: A retrospective analysis of 198 cases of ovarian cancer in patients with clinical data. By examining the expression of heparan sulfate proteoglycan-1 in all specimens and combining with the clinical data of the patients, the relationship between the expression of heparan sulfate proteoglycan-1 and the prognosis of the patients was analyzed. Results: The histological type of ovarian cancer was mainly of serous type. The positive expression of heparan sulfate proteoglycan-1 in 83.33% of mucinous ovarian cancer and clear cell ovarian cancer was significantly higher than that in other types of ovary Cancer (P <0.05). The positive rate of heparan sulfate proteoglycan-1 in interstitial cells was significantly increased (P <0.05) in ovarian cancer with low differentiation. The survival time of patients with positive expression of heparan sulfate proteoglycan-1 in tumor epithelial cells was significantly shorter than that in patients with negative expression of heparan sulfate proteoglycan-1 (P <0.05); the expression of heparan sulfate proteoglycan-1 Expression correlated with patient’s prognosis (P <0.05). Cox proportional hazards model analysis showed that FIGO stage, tumor histological grade, histological type of tumor, and the expression of heparan sulfate proteoglycan-1 were correlated with the prognosis of patients (P <0.05). CONCLUSION: The positive expression of heparan sulfate proteoglycan-1 may be related to the occurrence, invasion and metastasis of ovarian cancer, and has certain predictive value for the prognosis of patients with ovarian cancer.