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医学论坛网报道,台湾一项研究表明,与那些中断他汀药物治疗相比,连续应用亲脂性他汀药物治疗与帕金森病(PD)发生率减少有关,尤其是在女性和老年亚组患者中较为显著。论文7月24日在线发表于《神经病学》(Neurology)杂志。该研究纳入43810例无PD且初始启动他汀药物治疗的患者,利用Cox回归模型评估中断不同种类的他汀与PD发生的相关性。结果显示,亲脂性和亲水性他汀应用者的PD发生率分别为1.68和3.52/1000000人-天。与中断他汀治疗者相比,连续
A study in Taiwan showed that continuous administration of lipophilic statin therapy was associated with a reduced incidence of Parkinson’s disease (PD) compared with those discontinuing statin therapy, especially in women and the elderly subgroup Significant. The paper was published online July 24 in Neurology. The study enrolled 43,810 patients without PD and initially initiated statin therapy and used Cox regression models to assess the association of discontinuation of different classes of statins with PD. The results showed that the PD incidence of lipophilic and hydrophilic statin users was 1.68 and 3.52 / 1000000 person-days, respectively. Compared with interruption of statin treatment, continuous