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大剂量或长期服用阿斯匹林后,由于胃粘膜绉壁中未溶解的药物,在局部形成较高的浓度,引起严重的刺激作用,导致胃粘膜溃疡、腹部不适、恶心等。为了减轻对胃肠道的刺激,临床常同服一定量的碳酸氢钠(SB)。但是两药的配伍是否合理,目前看法不一,有人认为 SB 可升高胃液 pH,使阿斯匹林大部分转变成离子型从而减少吸收,且碱化尿液,加速排泄,从而降低血药浓度,降低疗效。也有人认为阿斯匹林在碱性溶液中吸收不受影响,在体内它的解离型与分子型以动态平衡存在,当分子型被吸收后离子型可以予以补充。基于上述不同观点,本实验设计了 SB 与阿斯匹林不同配比的四个处方,从药代动力学方面探讨了 SB 对阿斯匹林的影响,现报道如下。
High-dose or long-term use of aspirin, due to gastric mucosal crepe insoluble drugs in the local formation of higher concentrations, causing severe irritation, leading to gastric ulcer, abdominal discomfort, nausea and so on. In order to reduce gastrointestinal irritation, often with clinical services with a certain amount of sodium bicarbonate (SB). However, the compatibility of the two drugs is currently not the same opinion, some people think that SB can increase gastric pH, most of the aspirin into ionic to reduce absorption, and alkalinization of urine to accelerate excretion, thereby reducing blood pressure Concentration and reduce the effect. Some people think that aspirin absorption in alkaline solution is not affected in the body of its dissociation type and molecular type exist in dynamic equilibrium, when the molecular type is absorbed ion type can be added. Based on the above point of view, this experiment designed a different formula of SB and aspirin four prescriptions, pharmacokinetics from the SB to explore the impact of aspirin are reported below.