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目的对常用的抗抑郁药物艾司西酞普兰与文拉法辛治疗抑郁障碍进行成本-效果分析。方法将78例符合《中国精神障碍分类与诊断标准》（第三版）抑郁发作诊断标准的抑郁障碍患者随机分为两组，分别给予艾司西酞普兰或文拉法辛治疗8周，观察两组治疗方案的疗效及安全性，运用药物经济学的成本-效果分析方法进行评价。结果艾司西酞普兰、文拉法辛组治疗药品成本分别为663.04元和1164.80元；有效率分别为82.05%和84.62%；不良反应发生率分别为30.77%和28.21%。结论根据药物经济学评价，艾司西酞普兰组优于文拉法辛组。“,” Objective To commonly used antidepressant escitalopram and Vin Rafa Sin in the treatment of depression for cost-effectiveness analysis. Methods 78 patients with“Chinese classification and diagnostic criteria of mental disorders (Third Edition)”in patients with depressive disorder were randomly divided into depression diagnosis standard into two groups,were treated with escitalopram and venlafaxine in the treatment of 8 weeks, to observe the safety and efficacy of treatment group two, using the pharmacoeconomic cost-effectiveness analysis. Result Escitalopram, venlafaxine group therapy drug costs were 663.04 yuan and 1164.80 yuan; the effective rates were 82.05%and 84.62%;the incidence of adverse reaction was 30.77%and 28.21%respectively. Conclusion On the basis of pharmacoeconomic evaluation, escitalopram group was better than that of venlafaxine group.