细胞核相关抗原Ki-67是一种增殖细胞相关的核抗原,属于细胞核内的非组蛋白,在人类多种恶性肿瘤组织中存在过度表达,尤其是肺癌。Ki-67可反映非小细胞肺癌的发生、发展、转移,可作为其细胞增殖的标志之一。近年来研究发现,Ki-67虽不能很好地反映小细胞肺癌的生物学行为,但有助于其病理类型的判断。该文就Ki-67在肿瘤学方面,尤其是与不同类型肺癌间关系的相关研究予以综述。 Nuclear-associated antigen Ki-67 is a proliferating cell-associated nuclear antigen that belongs to the non-histone proteins in the nucleus. It is overexpressed in many human malignancies, especially lung cancer. Ki-67 can reflect the occurrence, development and metastasis of non-small cell lung cancer and can be used as one of the markers of cell proliferation. In recent years, the study found that although Ki-67 does not reflect the biological behavior of small cell lung cancer, but it helps to determine the pathological type. This article reviews the studies on Ki-67 in oncology, especially the relationship with different types of lung cancer.