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目的了解五华县手足口病病原学特征,为防控提供依据。方法采集五华县2010—2013年哨点医院手足口病病例粪便标本,用荧光定量PCR法进行肠道病毒71型(EV71)、柯萨奇病毒A组16型(CoxA16)和其他肠道病毒核酸检测。结果共检测214份标本,肠道病毒总检出率67.3%,其中EV71检出率17.8%、CoxA16型检出率14.5%、其他肠道病毒检出率35.0%;男女EV71、CoxA16和其他肠道病毒的检出率类似;手足口病主要病原2010年是EV71型,2011年至现在为其他肠道病毒;患儿检出率随年龄升高而降低,5岁以下病例占98.6%(142/144)。结论五华县手足口病感染率较高,开展手足口病流行病学和病原学研究,有助于提出有针对性的防控措施。
Objective To understand the etiological characteristics of hand, foot and mouth disease in Wuhua County and provide evidence for prevention and control. Methods Stool specimens of hand, foot and mouth disease from sentinel hospital in Wuhua County from 2010 to 2013 were collected. The expression of enterovirus 71 (EV71), CoxA16 and other enteroviruses Nucleic acid test. Results A total of 214 specimens were detected. The total detection rate of enterovirus was 67.3%, including 17.8% for EV71, 14.5% for CoxA16 and 35.0% for other enteroviruses; EV71, CoxA16 and other intestinal The detection rate of the virus was similar. The main pathogen of hand, foot and mouth disease was EV71 in 2010 and other enteroviruses from 2011 to now. The detection rate of children decreased with age, and 98.6% of cases under 5 years old (142 / 144). Conclusion The prevalence of hand-foot-mouth disease is high in Wuhua County, and the epidemiology and etiology research of hand-foot-mouth disease are helpful to propose targeted prevention and control measures.