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目的:探讨2型糖尿病伴不同程度血管病变患者血清可溶性细胞间黏附分子(sICAM-1)水平的变化及其意义。方法:91例2型糖尿病患者分为无血管并发症组22例(A组)、微血管病组13例(B组)、大血管病组31例(C组)和同时合并大血管和微血管病组25例(D组)。并设正常对照组35例。采用125I-sICAM-1放免分析(RIA)方法测定血清sICAM-1水平。结果:C组、D组血清sICAM-1水平高于A组、B组和对照组(P<0.05),A组、B组及对照组之间,C组、D组之间血清sICAM-1差异无统计学意义(P>0.05)。血清sICAM-1与甘油三酯、总胆固醇均呈正相关(rs分别为0.210和0.219,t分别为2.392和2.499,P<0.05)。结论:血清sICAM-1主要与糖尿病大血管病变有关,可作为糖尿病大血管病变病情变化的监测指标。
Objective: To investigate the changes of serum soluble intercellular adhesion molecule (sICAM-1) and its significance in type 2 diabetes mellitus patients with varying degrees of vascular disease. Methods: A total of 91 patients with type 2 diabetes were divided into 22 patients (group A) without vascular complications, 13 patients with microangiopathy (group B), 31 patients with macrovascular disease (group C) and patients with macrovascular and microvascular complications Group of 25 cases (D group). And set the normal control group of 35 cases. Serum levels of sICAM-1 were measured by 125I-sICAM-1 radioimmunoassay (RIA). Results: The serum levels of sICAM-1 in group C and group D were significantly higher than those in group A, B and control (P <0.05). The levels of sICAM-1 in group A, group B and control group, group C and group D The difference was not statistically significant (P> 0.05). Serum sICAM-1 and triglyceride, total cholesterol were positively correlated (rs = 0.210 and 0.219, respectively, t = 2.392 and 2.499, P <0.05). Conclusion: Serum sICAM-1 is mainly associated with diabetic macroangiopathy, which can be used as a monitoring indicator of diabetic macroangiopathy.