论文部分内容阅读
甲氟喹是治疗抗氯喹恶性疟的有效药物。但一些国家和地区尚未广泛使用,已报导恶性疟对该药出现抗性。为延迟其抗性的发生,现采用三种抗疟药(MSP)互用进行研究。治疗方案是用甲氟喹750mg,磺胺多辛1500mg,乙胺嘧啶75mg顿服。另以奎宁为对照,按10mg/kg体重给药,初次用奎宁静注,以后每隔8小时服1次,连服7天。实验对象为缅甸勃固山区66名恶性疟患者。该地区疟疾高度流行,已报告恶性疟对氯喹和磺胺多辛有抗性。治疗对象还具有
Mefloquine is an effective drug for the treatment of falciparum resistant to chloroquine. However, some countries and regions have not yet been widely used and have reported that P. falciparum is resistant to the drug. To delay the development of their resistance, three antimalarial drugs (MSPs) were used to study the interaction. Treatment regimen is mefloquine 750mg, sulfadoxine 1500mg, pyrimethamine 75mg Dayton clothing. Another quinine as a control, according to 10mg / kg body weight administered for the first time with quinine intravenously, after every 8 hours a service, and even served 7 days. The subjects were 66 patients with falciparum malaria in Burg region of Myanmar. Malaria is highly prevalent in the region and has been reported to be resistant to chloroquine and sulfadoxine. The treatment object also has