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目的探讨女性不孕患者解脲脲原体(UU)不同生物群与抗精子抗体(ASA)的相关性。方法对80例女性不孕者(观察组)及80例健康孕妇(对照组)行UU及其生物群检测,采用ELISA法检测ASA阳性率;分析UU与ASA的相关性。结果观察组UU及其T960生物群与ASA阳性率均明显高于对照组(P<0.01),观察组UU以T960生物群为主;对照组UU主要以Parvo生物群为主。两组Parvo生物群比较无统计学意义。观察组ASA阳性者UU及T960生物群感染率明显高于ASA阴性者(P<0.01),两者Parvo生物群差异无统计学意义。结论女性不孕的发生与UU及ASA有关;T960生物群更容易引起不孕。
Objective To investigate the relationship between different biota of UU and antisperm antibody (ASA) in female infertility patients. Methods Eighty female infertility patients (observation group) and 80 healthy pregnant women (control group) were tested for UU and its biome. The positive rate of ASA was detected by ELISA. The correlation between UU and ASA was analyzed. Results The positive rates of UU, T960 and ASA in the observation group were significantly higher than those in the control group (P <0.01). The UU in the observation group was dominated by the T960 biota. The UU in the control group was mainly dominated by the Parvo biota. The Parvo biota between the two groups showed no statistical significance. The infection rate of UU and T960 in ASA positive observation group was significantly higher than that in ASA negative observation group (P <0.01). There was no significant difference between Parvo biota and control group. Conclusion The occurrence of female infertility is related to UU and ASA. T960 biotic group is more likely to cause infertility.