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目的探讨利用平板探测器血管造影系统进行脑血容量(CBV)检查的可行性和临床价值。方法采用前瞻性自身对照研究方法,对2010年6月至2011年3月诊断为脑缺血疾病并接受介入治疗的20例患者,采用静脉注射对比剂方法进行了灌注CT(PCT)和平板CT(FDCT)的检查,采用配对分析两种检查结果在不同部位、不同血管条件下的CBV差异。结果 20例患者均顺利完成FDCT和PCT检查,两种方法均未见明显的两侧灌注差异,但与健侧相比,患侧CBV有减少趋势。两种方法所得数据的Person相关系数为0.68,提示两者显著相关。Bland-Altman检验提示两种检查方法的同一部位差异值平均为-0.25±2.79,FDCT-CBV数值较PCT-CBV数值略低。结论 FDCT-CBV检查方法在临床上具有可行性,所得结果与PCT-CBV无明显差异。FDCT-CBV可以在手术全过程中提供全脑功能影像,增强了手术计划性,提高了手术安全性。
Objective To explore the feasibility and clinical value of using the flat panel detector angiography system for cerebral blood volume (CBV) examination. Methods A prospective, self-controlled study was conducted in 20 patients diagnosed with ischemic brain disease and interventional therapy from June 2010 to March 2011. Intravenous contrast medium was used to perfuse CT and PCT (FDCT) examination, paired analysis of the two test results in different parts of the CBV differences under different vascular conditions. Results All 20 patients underwent FDCT and PCT examinations successfully. There was no significant difference between the two groups in perfusion. However, compared with contralateral side, the contralateral CBV showed a decreasing trend. The Person correlation coefficient of the data obtained by the two methods was 0.68, suggesting a significant correlation between the two. The Bland-Altman test showed that the mean difference between the two methods was -0.25 ± 2.79, and the value of FDCT-CBV was slightly lower than that of PCT-CBV. Conclusion The FDCT-CBV examination method is clinically feasible and the results obtained are not significantly different from those of PCT-CBV. FDCT-CBV can provide whole-brain imaging during the whole operation, which enhances the planning of operation and improves the safety of operation.