在恶性肿瘤化疗的50多年历史中,人们一直在探讨能提高药物抗肿瘤作用、降低其毒性反应的方法,目前常用的一种是联合用药,使其对肿瘤细胞毒性作用协同,而对人体的副作用不增加;另一方法是改变给药途径,从静脉全身化疗转换为经动脉灌注局部化疗,即介入化疗,以提高疗效,减少副作用 In the more than 50 years of chemotherapy for malignant tumors, people have been exploring ways to improve the anti-tumor effect of drugs and reduce their toxic reactions. One of the commonly used methods is to combine drugs to make cytotoxicity of tumor cells synergistic, Side effects do not increase; the other way is to change the route of administration, from intravenous systemic chemotherapy into arterial infusion of local chemotherapy, interventional chemotherapy to improve efficacy and reduce side effects