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目的了解凝血酶原基因(prothrombinfactorⅡ,FⅡ)3′UTG20210A变异在中国壮族人群的分布频率及在心脑血栓患者中是否具有突变“优势”,试图证明该突变点是否与动脉血栓形成相关。方法通过小规模的“群体对照”研究,应用聚合酶链式反应限制性酶切分析方法,调查76例缺血性脑卒中及23例心肌梗塞患者与106名无血栓病史健康对照者的FⅡG20210A变异。结果患者及健康对照均为FⅡG20210G纯合子,未发现任何FⅡG20210A变异者。结论106名壮族正常人与99例缺血性脑卒中及心肌梗塞患者中不存在FⅡ3′UTG20210A变异;FⅡG20210A变异不足以作为中国人血栓形成的危险因素。
Objective To investigate the frequency of 3’UTG20210A mutation in prothrombin factor (FⅡ) gene in Chinese Zhuang population and whether there is a mutation “predominance” in patients with cardiocerebral thrombosis in order to prove whether the mutation is related to arterial thrombosis. Methods A small-scale “population control” study was used to detect the F Ⅱ G20210A mutation in 76 patients with ischemic stroke and 23 patients with myocardial infarction and 106 healthy controls without thrombosis using polymerase chain reaction restriction analysis . Results All patients and healthy controls were FⅡG20210G homozygotes, and no mutation of FⅡG20210A was found. Conclusion There are no FⅡ3’UTG20210A mutations in 106 Zhuang normal subjects and 99 ischemic stroke patients and myocardial infarction patients. FⅡG20210A mutation is not enough to be a risk factor for thrombosis in Chinese.