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目的:对比药物洗脱支架(DES)置入术后不同时期发生支架内血栓(ST)患者的临床预后。方法:入选2005-01至2015-04我院经冠状动脉造影证实的DES置入术后发生ST患者131例。根据ST发生时间分为早期ST组42例(≤30天)和晚期ST组89例(>30天)。收集两组患者住院期间资料及随访结果,对比DES置入术后不同时期发生支架内血栓(ST)患者的临床预后。结果:早期ST组住院期间主要不良心血管事件(MACE)发生率高于晚期ST组(16.7%vs 4.5%,P=0.04)。123例患者存活出院,随访时间为中位数38.00(15.00,62.00)个月。Kaplan-Meier分析,两组估测无MACE生存率分别为41.9%和36.3%,差异无统计学意义(P=0.43)。结论:DES置入术后早期发生ST患者住院期间MACE发生率高于晚期发生ST患者,但两组远期预后差异无统计学意义。
OBJECTIVE: To compare the clinical outcomes of patients with stent thrombosis (ST) at different stages after drug-eluting stent (DES) implantation. Methods: Selected from January 2005 to April 2015, our hospital had 131 cases of ST patients confirmed by coronary angiography. According to the time of onset of ST, there were 42 cases (≤30 days) in the early ST group and 89 cases (> 30 days) in the advanced ST group. The duration of hospitalization and the follow-up of the two groups were collected to compare the clinical outcomes of patients with stent thrombosis (ST) at different stages after DES implantation. Results: The incidence of major adverse cardiovascular events (MACE) in the early ST group was significantly higher than that in the late ST group (16.7% vs 4.5%, P = 0.04). 123 patients were discharged alive, the median follow-up time was 38.00 (15.00,62.00) months. According to Kaplan-Meier analysis, there was no significant difference in MACE survival between the two groups (41.9% and 36.3%, respectively) (P = 0.43). Conclusions: The incidence of MACE during hospitalization during the early postoperative period of DES is higher than that of patients with advanced ST. However, there is no significant difference in long-term prognosis between the two groups.